APC or Apc or may refer to:
- A.P.C., A french design group and clothing retailer
- Alianza Popular Conservadora, a political party in Nicaragua
- Alien Property Custodian
- All People's Congress, a political party of Sierra Leone
- American Pie Council, an organization committed to preserving America's pie heritage
- American Plastics Council, a major trade association for the U.S. plastics industry
- APC by Schneider Electric, critical power and cooling services
- American Presbyterian Church, a Reformed Christian denomination in the United States
- Animal Procedures Committee, a UK public body and task force
- Anti-Poverty Committee, a direct action organization in Vancouver, Canada
- Arab Potash Company in Jordan
- Armed Proletarians for Communism, an Italian far-left terrorist group of the 1970s
- Arrangers' Publishing Company, a sheet music publishing company in the United States
- Asia Pacific College, a joint venture between IBM Philippines and the SM Foundation
- Associated Presbyterian Churches, a Scottish Christian denomination
- Association for Progressive Communications, an association for providing communication infrastructure
- aPOCALYPSE pRODUCTION cREW, an MP3 warez organization
- A Perfect Circle, an alternative rock band
- Apc, Hungary, a village in the Heves county of Hungary
- Argon plasma coagulation, an endoscopic technique for controlling hemorrhage
- Attoparsec, an unusual unit of measurement
- Napa County Airport (IATA airport code), near Napa, California
- Atari Punk Console, a simple DIY noisemaker circuit
- Australian Provincial Championship, a rugby union competition in Australia
- Automatic Performance Control, a system that was used on some Saab H engines
- Average propensity to consume, the proportion of income spent
- Assessment of Professional Competence, the practical training and experience which leads to Royal Institution of Chartered Surveyors membership